Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Saini, Vipin
- Dissolution Method Development and Validation for Combination Dosage Form of Telmisartan and Nebivolol hydrochloride Tablets using UV Spectrophotometric Method
Abstract Views :177 |
PDF Views:0
Authors
Chinmoy Kumar
1,
Manish Kumar
1,
Vipin Saini
2,
Shailendra Bhatt
1,
A. Pandurangan
1,
Anuj Malik
1,
Preeti Pal
1,
Laxmi Narayan Shetty
3
Affiliations
1 M M College of Pharmacy, Markandeshwar (Deemed to be University), Mullana, Ambala-133207, Haryana, IN
2 M M University, Solan, Himachal Pradesh, IN
3 Reginal Drugs Testing Laboratory, Ballari, Karnataka, IN
1 M M College of Pharmacy, Markandeshwar (Deemed to be University), Mullana, Ambala-133207, Haryana, IN
2 M M University, Solan, Himachal Pradesh, IN
3 Reginal Drugs Testing Laboratory, Ballari, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2742-2747Abstract
The combination tablets dosage form of Telmisartan and Nebivolol hydrochloride dissolution method was developed by UV spectrophotometer and validated was according to the ICH guidelines. The any official method of this combination drugs was not available. In this proposed method two commercial brands of drug was used. The simultaneous estimation of Telmisartan and Nebivolol hydrochloride was performed in this proposed method which includes to solving of simultaneous equation. The wavelength of Telmisartan 296nm and 281nm of Nebivolol hydrochloride was used in this simultaneous equation. The dissolution mediums such as 0.1N HCl, phosphate buffer, SFG (without enzyme) at various ph was used in this method. The selected proposed dissolution method was SFG dissolution media (without enzyme) 900 ml, speed 75 rpm, USP type II apparatus and temperature at 37 ± 0.5°C and drug release than 85% within 45mints. The optimized proposed method easy to handle and commercially used for the routine quality control checking of Telmisartan and Nebivolol hydrochloride pharmaceutical combine tablets dosage form.Keywords
Telmisartan, Nebivolol Hydrochloride, Simultaneous Equation, Dissolution, Validation, ICH Guidelines.References
- Dressman J, Kramer J. Pharmaceutical dissolution testing. Taylor and Francis group, editors. Dissolution testing: Guidance for industry. New York: Marcel Dekker; 352 – 53, 2005.
- Lesson LJ. Invitro/in vivo correlations. Drug Information Journal 1995; 29:903-915.
- Vaucher LC. Development and validation of a dissolution test for telithromycin in coated tablets. Quimica Nova 2009, 32(5):1–5.
- Harika, CH, Raja Jaya Rao Y, Gousia Parvin SK, Siva Shankar Sastry CH. Formulation and evaluation of Nebivolol tablets. International Journal of Pharmaceutical Archive 2013, 2(11): 251-258.
- Judy, WMC, Nebivolol: A third-generation _-blocker for hypertension. Cli. Therapeutics, 2009, 31(3):447-62.
- Budavari, S. O’Neil, M.J. Smith, A, Heckelman, PE. , Ed. The Merck Index, Mary Adele 13th edition published by Merck Research Lab, Division of Merck and Co, White house station, NJ, USA, 148.2001.
- Dressman JB, Amidon GL, Reppas C, Shah VP, Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Immediate Release Dosage Forms, Pharmaceutical Research 1998, 15(1):11–22.
- Sweetman SC. Martindale, the Complete Drug Reference. 34th edition. The Pharmaceutical Press, Great Britain 2002: 48-76.
- Beckett AH, Stenlake JB. Practical pharmaceutical chemistry. Fourth edition part II. New York: Continuum international publishing group 284-286, 2001.
- Khan F, Lohiya RT, Umekar MJ. Development of UV Spectrophotometric method of the simultaneous estimation of Meloxicum and Paracetamol in Tablet by simultaneous Equation, Absorbance ration and Absorbance Correction method. International Journal of Chem Tech Research, 2010: 2 (3).
- Garcia CV, Paim CS. Steppe M, Schapoval, EES. Development and validation of a dissolution test for rabeprazole sodium in coated tablets. Journal of Pharmaceutical and Biomedical Analysis 2006, 641(3): 833–837.
- International Conference on Harmonization Q2 (R1). Draft Guideline on Validation of Analytical Procedures: Definitions and Terminology, Federal Register. 60, 11260.
- Patel PA, Patravale. VB, Commercial Telmisartan Tablets: A Comparative Evaluation with Innovator. Brand Micardis, International Journal of Pharma Sciences and Research, 2010, 1 (8): 282–292.
- Shohin IE, Kucinich JI, Ramensakya GV, Vasilenko GF, Evaluation of In Vitro Equivalence for Drugs Containing BCS Class II Compound Ketoprofen, Dissolution Technologies 2011, 18 (1): 26–29.
- Gowthamarajan K, Singh SK, Dissolution Testing for Poorly Soluble Drugs: A Continuing Perspective, Dissolution Technologies 2010, 17(3): 24–32.
- The United States Pharmacopeia and National Formulary USP 27–NF 24, the United States Pharmacopeial Convention, Inc.: Rockville, MD, 2007.
- Uv-visible Spectrophotometric Method Development and Validation for the Estimation of Curcumin and Tetrahydrocurcumin
Abstract Views :70 |
PDF Views:0
Authors
Affiliations
1 MM College of Pharmacy, MM (Deemed to be) University, Mullana, Ambala, Haryana,, IN
2 MM School of Pharmacy, MM University, Sadopur, Ambala, Haryana,, IN
3 Maharishi Markandeshwar University, Solan, HP,, IN
1 MM College of Pharmacy, MM (Deemed to be) University, Mullana, Ambala, Haryana,, IN
2 MM School of Pharmacy, MM University, Sadopur, Ambala, Haryana,, IN
3 Maharishi Markandeshwar University, Solan, HP,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 650-654Abstract
Background: Curcumin shows degradation in the solution of high pH. There is a need for development of a method which can estimate the drug release precisely and accurately. The UV spectroscopy due to its simplicity and specificity is the most popular for method development for the determination of drugs. Objective: The present study was aimed to develop the UV-Visible spectrophotometric method for the assessment of curcumin and tetrahydrocurcumin (THC) using a stable solvent system. Method: The solubility of curcumin and tetrahydrocurcumin was determined at various physiological pH levels. Non-ionic surfactant, tween 80 was used with selected media to avoid the degradation of drugs. The selected solvent system was further validated according to guidelines of the international conference on harmonization (ICH) and the analytical parameters like linearity, veracity, sensitivity and accuracy were studied. Results: The solvent systems Phosphate buffer of pH 6.8+2% tween 80 and Phosphate buffer of pH 6.8+1% tween 80 were found optimum for estimation of curcumin and THC respectively. All the validation parameters were found within the range for developed methods. Conclusion: The proposed method is very simple and can be used for routine quality control testing of curcumin and tetrahydrocurcumin.Keywords
Curcumin, Tetrahydrocurcumin, Phosphate buffer pH 6.8, Tween 80, UV-Visible spectrophotometric method development.References
- Krishna Veni N, Meyyanathan SN, Rajinikanth BR, Elango K. A liquid chromatography method for the simultaneous determination of curcumin and piperine in food products using diode array detection. Asian J. Research Chem. 2009; 2(2): 115-118.
- Wandhare MD, Deokate UA, Khadabadi SS, Hadke SP, Sawarkar HA. Comparative Estimation of Curcumin Content from Marketed Herbal Anti Rheumatic Tablets Formulation. Asian J. Research Chem., 2009; 2(3): 340-3.
- Nair TS, Meghana R, Shlini P. Antimicrobial Activity of the protein fraction obtained in the extraction of Curcumin. Asian J. Research Chem., 2019;12(4): 199-202.
- Kollipara RK, Tallapaneni V, Sanapalli BK, Kumar GV, Karri VV. Curcumin loaded ethosomal vesicular drug delivery system for the treatment of melanoma skin cancer. Research J. Pharm. and Tech., 2019;12(4): 1783-92.
- Sweetha G, Sangeetha B, Prabhu S. A review on curcumin nanoparticles and its controlled delivery to treat degenerative diseases. Asian J. Pharm. Tech., 2013; 28;3(4): 218-22.
- Holder GM, Plummer JL, Ryan AJ. The metabolism and excretion of curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) in the rat. Xenobiotica. 1978;8(12):761-8.
- Mahal A, Wu P, Jiang ZH, Wei X. Schiff bases of tetrahydrocurcumin as potential anticancer agents. ChemistrySelect., 2019;4(1):366-9.
- Xi J, Luo X, Wang Y, Li J, Guo L, Wu G, Li Q. Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Exp. Ther. Med., 2019;18(5):3681-7.
- Murugan P, Pari L. Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats. J. Ethnopharmacol., 2007;113(3):479-86.
- Kimura S, Kiriyama A, Araki K, Yoshizumi M, Enomura M, Inoue D, et al. Novel strategy for improving the bioavailability of curcumin based on a new membrane transport mechanism that directly involves solid particles. Eur J Pharm and Biopharm., 2018;122:1-5.
- Pari L, Murugan P. Changes in glycoprotein components in streptozotocin-nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa. Plant Food Hum. Nut., 2007 1;62(1):25-9.
- Jayandran M, Haneefa MM, Balasubramanian V. Synthesis, Characterization and antimicrobial activities of turmeric curcumin and curcumin stabilized zinc nanoparticles-A green approach. Research J. Pharm. and Tech., 2015;8(4):445.
- Rramaswamy R, Mani G, Venkatachalam S, Yasam RV, Rajendran JB, Tae JH. Preparation and characterization of tetrahydrocurcumin-loaded cellulose acetate phthalate/polyethylene glycol electrospun nanofibers. AAPS PharmSciTech., 2018;19(7):3000-8.
- Rapalli VK, Kaul V, Gorantla S, Waghule T, Dubey SK, Pandey MM, et al. UV Spectrophotometric method for characterization of curcumin loaded nanostructured lipid nanocarriers in simulated conditions: method development, in-vitro and ex-vivo applications in topical delivery. Spectrochimica Acta A,. 2020;224:117392.
- Mondal S, Ghosh S, Moulik SP. Stability of curcumin in different solvent and solution media: UV–visible and steady-state fluorescence spectral study. J. Photochem. Photobiol. B, Biol., 2016;158:212-8.
- Aggarwal BB, Deb L, Prasad S. Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules., 2015;20(1):185-205.
- Majumder KK, Sharma JB, Kumar M, Bhatt S, Saini V. Development and Validation of UV-Visible Spectrophotometric Method for The Estimation of Curcumin in Bulk and Pharmaceutical Formulation. Pharmacophores., 2020; 10(1):115-21.
- Martínez-Guerra J, Palomar-Pardavé M, Romero-Romo M, Corona-Avendaño S, Rojas-Hernández A, Ramírez-Silva MT. New insights on the Chemical Stability of Curcumin in Aqueous Media at Different pH: Influence of the Experimental Conditions. Int. J. Electrochem. Sci., 2019;14:5373-85.
- He P, Yan H, Zhao J, Gou M, Li X. An evaluation of the wound healing potential of tetrahydrocurcumin-loaded MPEG-PLA nanoparticles. J. Biomater. Appl., 2019;34(3):315-25.
- Ajay S, Harita D, Tarique M, Amin P. Solubility and dissolution rate enhancement of curcumin using kollidon VA64 by solid dispersion technique. Int J Pharm Tech Res., 2012; 4:1055-64.
- ICH-Guidelines Q2(R1). Validation of Analytical Procedures: Text and Methodology. Geneva, Switzerland: 2005.
- Pramod K, Ansari SH, Ali J. UV Spectrophotometric Method for the Quantification of Eugenol during in Vitro Release Studies. Asian J. Pharm. Ana., 2013;3(3):86-9.
- Patidar M, Gopkumar P, Sridevi G, Behera CC, Pillai S. Development and Validation of RP-HPLC Method for Simultaneous Determination of Resveratrol and Curcumin in Pure Form. Research J. Pharm. and Tech., 2013;6(9):990-2.
- Tang Y, Fields C. A UHPLC-UV Method development and validation for determining kavalactones and flavokavains in Piper methysticum (Kava). Molecules., 2019;24(7):1245.
- Nagarnaik M, Sarjoshi A, Bodkhe A, Khanal B, Pise M, Pandya G. Characterization of active constituents in Turmeric powder and validation of method for curcumin in samples. Asian J. Research Chem., 2015;8(10):643-7.
- Sahu S, Kumari K, Muduli NR, Moharana AK. Development of UV Spectrophotometry Absorption correction method for estimation of Curcumin and Aspirin from Bulk. Research J. Pharm. and Tech., 2019;12(10):4857-60.
- Rahman SM, Telny TC, Ravi TK, Kuppusamy S. Role of surfactant and pH in dissolution of curcumin. Indian J. Pharma. Sci., 2009;71(2):139.
- Trivedi MK, Panda P, Sethi KK, Gangwar M, Mondal SC, Jana S. Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, and NMR and its biological activities. J. Pharm. Anal., 2020;10(4):334-45.